Derma filler is specifically designed for deeper lines and wrinkles. Many times both fillers are used at one session depending on the correction required. Your provider will recommend what is best for your concerns. The goal is to get you the longest duration possible. Your provider will also prepare you for the injection with an anesthetic block, numbing cream, or ice. There are numerous areas that are possible for treatment, including lips, nasal folds, and marionette lines around the mouth and under the eyes. Cheeks and other areas can also be enhanced with Derma fillers .